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The short- and long-term impacts of nanoparticles (NPs) in consumer products are not fully understood. Current European Union (EU) regulations enforce transparency on products containing NPs in cosmetic formulations; however, those set by the U.S. Food and Drug Administration are lacking. This study demonstrates the potential of single-particle inductively coupled plasma tandem mass spectrometry (spICP-MS/MS) as a screening method for NPs present in powder-based facial cosmetics (herein referred to as FCs). A proposed spICP-MS/MS method is presented along with recommended criteria to confirm particle presence and particle detection thresholds in seven FCs. FC products of varying colors, market values, and applications were analyzed for the presence of Bi, Cr, Mg, Mn, Pb, Sn, Ag, Al, and Zn NPs based on their ingredient lists as well as those commonly used in cosmetic formulations. The presence of NPs smaller than 100 nm was observed in all FC samples, and no correlations with their presence and market value were observed. Here, we report qualitative and semi-quantitative results for seven FC samples ranging in color, brand, and shimmer.